Many types of cancer tumors can develop by eating more protein. It has been revealed in a recent study. These days different types of proteins are being investigated. By whom efforts are being made to find out how protein works in cancer cells. Clinical Proteomic Tumor Analysis Consortium Key cancer-causing proteins and how they are regulated. The study involved people from the Washington University School of Medicine in St. Louis, the Broad Institute at MIT and Harvard, Brigham Young University and other schools. The study results have been published in the journal Cell and Cancer Cell. The Clinical Proteomic Tumor Analysis Consortium is funded by the National Cancer Institute of the National Institutes of Health (NIH).
'This new analysis of proteins that drive tumor growth is an important addition to cancer genome sequencing in our efforts to develop better cancer treatments,' said senior author Li Ding, PhD, the David English Smith Distinguished Professor of Medicine at the University of Washington. After is the next step. Through our previous work sequencing the genomes of cancer cells, we have identified approximately 300 cancer-causing genes. Now, we are studying the details of the machinery that triggers these cancer genes. The proteins and their regulatory networks that actually cause uncontrolled cell division. We hope that this analysis will serve as an important resource for cancer researchers seeking to develop new treatments for many types of tumors.
The researchers analyzed nearly 10,000 proteins involved in 10 different cancer types. Ding emphasized the importance of large amounts of data in this type of analysis. Many of these important cancer-induced proteins are rare in any single cancer and would not have been identified if tumor types had been studied separately. The analysis included two different types of lung cancer, as well as colorectal, ovarian, kidney, head and neck, uterine, pancreatic, breast and brain cancers.
"Many cancer-causing proteins are found in many types of tumors, but at a low frequency," said Ding, research member of the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. When we analyze cancer cells, we increase the power to detect key proteins that are driving cancer growth and spread. A combined analysis also allows us to pinpoint the major common mechanisms driving the different types of cancer.
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